Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6, also Corticosteroid-Binding Globulin or Transcortin | |
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Structure of corticosteroid-binding globulin in complex with cortisol. | |
Identifiers | |
Symbol | SERPINA6 |
Alt. symbols | CBG |
Entrez | 866 |
HUGO | 1540 |
OMIM | 122500 |
RefSeq | NM_001750 |
UniProt | P08185 |
Other data | |
Locus | Chr. 14 q32.1 |
Transcortin, also corticosteroid-binding globulin or CBG, is officially called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6.
It is an alpha-globulin.
Contents |
Transcortin binds several steroid hormones:
Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
Mutations in this gene are rare. To date only five cases have been reported.[1] All cases have been associated with generalised pain and fatigue. This mechanism for these symptoms is not known. This condition must be distinguished from secondary hypocortisolism. Exogenous hydrocortisone does not appear to improve the fatigue.
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